Inventiva and Curie-Cancer announce a partnership in Epigenetics.

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Curie-Cancer and Inventiva announce a partnership in epigenetics for the treatment of cancer

Led by the Institut Curie and Inventiva, the multi-million euro Epicure project has just been selected for funding by France’s national research agency

Paris and Dijon, France, September 16, 2014 – Curie-Cancer, the body responsible for developing Institut Curie’s industry partnership activities, and Inventiva, a drug discovery company that focuses on therapeutic approaches involving transcription factors and epigenetic targets, today announce the launch of the Epicure project, which has just received financial backing from France’s national research agency, the ANR [Agence Nationale pour la Recherche].

The Epicure project focuses on two novel epigenetic targets implicated in immunomodulation. It aims to confirm their therapeutic potential for the treatment of cancers such as breast cancer, ovarian cancer and melanoma, as well as some respiratory diseases. It also aims to identify molecules that are capable of regulating the activity of the targets and are therefore likely to become active drugs for the treatment of these diseases. The funding provided by the ANR covers a period of four years.

A new therapeutic approach for treating cancer

The Epicure project will involve three teams from the Institut Curie: the Epigenetics team led by Geneviève Almouzni, director of research at the French national center for scientific research the CNRS [Centre national de recherche scientifique], and director of the research center at the Institut Curie, the Immunology team headed by Sebastian Amigorena, director of research at the CNRS, and Sergio Roman-Roman’s Translational Research team. Inventiva’s epigenetics drug discovery team will join and partner with Curie teams.

The purpose of the Epicure project is to produce novel molecules that modulate the epigenetic targets under evaluation. These would be ready to go into clinical development upon completion of the project. Its ultimate goal is to find new drugs that will activate immune responses against cancer cells.

“The ANR funding provides additional resources for the partnership we have established with the Institut Curie. It adds to our portfolio of epigenetic programs, which aims to confirm novel epigenetic mechanisms and develop innovative drugs to treat cancer,” said Pierre Broqua, co-founder and scientific director of Inventiva. “By combining our expertise in target validation and drug discovery with the Institut Curie’s skills in basic and translational oncology research, we can achieve rapid and significant outcomes for patients.”

Curie-Cancer hand in hand with Inventiva

“In Curie-Cancer, we have found all the expertise and support that we need to roll out our epigenetic strategy,” said Frederic Cren, CEO and co-founder of Inventiva. “For an innovative business like ours, it is very important to have the support of a world-renowned center like the Institut Curie. Its expertise complements ours, particularly in the fundamental knowledge of biology and the treatment of cancer.”

“Beyond the prospect of quickly providing an additional therapeutic solution for our patients, we are delighted to support a French business in its plans for growth,” said Damien Salauze, director of Curie-Cancer. “Once again, the expertise developed at the Institut Curie also meets the stated requirements of our industry partners. This is embodied in our Carnot label, which was awarded in 2011 in recognition of our commitment to providing practical solutions to our industry partners and, in due course, to patients.”

About Curie-Cancer

Curie-Cancer is the body responsible for developing Institut Curie’s industry partnership activities. It oversees the institute’s existing industry partnerships as well as areas of high potential interest to industry partners. Institut Curie’s 1,200 researchers provide the high level of expertise in oncology required to collaborate with industry partners in creating and subsequently developing cancer therapies.

Curie-Cancer management has extensive industry experience and can call upon a vast pool of scientists involved in basic and clinical research. In 2011, Curie-Cancer was awarded the ‘Institut Carnot’ label by the French government, which recognizes excellence and involvement in research partnerships.

About Institut Curie

Institut Curie is a private foundation founded in 1909 by Marie Curie, the first woman Nobel prize-winner and the first double Nobel prize-winner. It is the leading comprehensive cancer center (combining research and patient care) in Europe. Institut Curie’s research center and hospital employ some 3,200 scientists, physicians, nurses, technicians and administrative staff. The institute’s current objectives include increasing the proportion of research programs carried out in partnership with industry so that research results can lead to faster availability of products and services for the benefit of patients.

For more information, go to: http://www.curie.fr/en

About Inventiva

Inventiva is a drug discovery company that focuses on therapeutic approaches involving transcription factors and epigenetic targets (particularly the HKMT family) to discover innovative treatments for cancer, fibrosis, immuno-inflammatory diseases and Parkinson’s disease.

Inventiva leads in-house research programs and secures drug discovery partnerships with pharmaceutical groups. It also offers a full range of research services, drawing on its extensive technology platform, its proprietary library of 240,000 compounds and its expertise in nuclear receptors, transcription factors and epigenetic modulation.

Inventiva boasts an experienced staff of over 100 employees, based at its research center in Daix, near Dijon (France).

More information: www.inventivapharma.com

CONTACT CURIE-CANCER

Damien Salauze
damien.salauze@curie.fr

PRESS Contacts

Sarah Morgan / Céline Gonzalez
Andrew Lloyd & Associates
sarah@ala.com / celine@ala.com

Tel. +44 (0)1273 675 100 | 01 56 54 07 00

Contact INVENTIVA

Frédéric Cren
frederic.cren@inventivapharma.com

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